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Both belong to a new generation of injectable peptide-based therapies that work by targeting multiple hormonal pathways simultaneously, offering potentially greater metabolic benefits than earlier single-receptor agents

Interestingly, previous studies have shown that pancreatic islets from diet-induced obese adult mice display decreased glucose-stimulated insulin secretion when treated with semaglutide, while no effect of semaglutide was detected on the islets of AIN93-fed mice [44]

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