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The strongest evidence in this domain supports the association between GHRH-related signaling, preserved pulsatility, and neuroendocrine rhythm research, but it's not definitive for this specific blend independently altering sleep architecture

Of note, intracerebroventricular injection of the MOR antagonist naloxone has also been shown to improve opioid-induced constipation 11 , suggesting a role for the brain-gut axis in this condition 12,13