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In in vitro cell experiments using 3T3L1 preadipocytes as a model, treatment with NNMTi significantly reduced preadipocyte differentiation efficiency and markedly downregulated the expression of adipocyte markers (such as PPAR and C/EBP) in a dosedependent manner

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Once B12 deficiency has been identified and treatment commenced, it is important to allow sufficient time for red blood cell populations to normalise before repeating HbA1c testing