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Remaining at a lower dose longer GLP-1 medications are typically started at a low dose and increased gradually to improve tolerability

In line with this hypothesis, an observational study of 200 adults with type 1 diabetes demonstrated improvements in albuminuria and in eGFR with SGLT2i use over 12 months among adults with a baseline eGFR 7000 participants identified a 2.8-fold greater risk of DKA with SGLT2i use compared with placebo in adults with type 1 diabetes [44]

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This double agonist approach seems to cause people who use Zepbound and Mounjaro injections to lose more weight than those who use single-agonist medication like Ozempic and Wegovy