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Clinical trials in the 2010s expanded cardiovascular applications within this drug class, with the Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results (LEADER) trial and the Trial to Evaluate Cardiovascular and Other Long-term Outcomes with Semaglutide in Subjects with Type 2 Diabetes (SUSTAIN-6) demonstrating that liraglutide and semaglutide reduced major adverse cardiovascular events (MACE) in type 2 diabetes patients with high cardiovascular risk
All experimental data are presented as mean SEM
10.1126/science.1104816 Science 9 BaertF.MatthysC.MaselyneJ.Van PouckeC.Van CoillieE.BergmansB.et al (2021)
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