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However, it is absolutely critical to emphasize that this microdosing or twice-weekly approach for semaglutide is considered an OFF-LABEL application

Semaglutide targets the GLP-1 receptor, while Tirzepatide targets both GLP-1 and GIP hormone receptors, providing a dual effect that may help enhance weight loss outcomes

Unlike exenatide which was based on exendin-4, semaglutide is based on the structure of human GLP-1 with specific modifications to improve its pharmacological properties

Semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, has gained significant attention for weight management beyond its original diabetes indication