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10.1007/s00425-006-0461-3 Planta 34 Iturbe-OrmaetxeI.HerasB.MatamorosM

They observed that metformin could downregulate the expression of MMP-9/MMP-2 and mTOR while upregulating the expression of protein kinase B and adenosine monophosphate-activated protein kinase (AMPK), thereby inhibiting ovarian granulosa cells dysfunction and promoting their recovery of follicle function ( in vitro studies utilizing human granulosa tumor-derived cell models demonstrates that metformin intervention effectively downregulates multiple components of the LPS-activated inflammatory cascade, including LPS-induced miR-670-3p , NOX2 , NLRP3 , ASC , and GSDMD-N , as well as reducing cellular caspase-1 activity, ROS production, and secretion of inflammatory factors

I just think it's so siloed and so compartmentalized and everybody's fighting for that extra dollar that quarter, that day, that month, that they're just blocking and tackling and preventing the narrative from rising in their siloed bucket

After 36 h of culture, luciferase activity was measured by Fluorescence detector