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For instance, the cholesterol biosynthesis pathway is downregulated in MS and in astrocytes in the poorly remyelinating model EAE 119 , and single nuclei sequencing of chronic active MS lesions indicate altered lipid storage/response genes in microglia and astrocytes 47

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FIGURE 7 The study was repeated using the same rat model to compare responses to 10, 25 and 50 g semaglutide applied to the intestinal surface versus 10-fold lower doses applied via the i.v