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comprehensive approach usually includes an appropriate baseline diet, review of factors that may alter levels and, when there is a risk or a confirmed deficiency, specific measures with a healthcare professional

The experimental EC 50 values were generated using in vitro cell-based activity assays

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However, some studies have found increased GABA concentrations and GABA/creatine ratios in the left dorsolateral prefrontal cortex of adult ASD patients, which may support the excitation/inhibition (E/I) imbalance hypothesis, suggesting enhanced inhibitory function in this region (132, 133)