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10.1021/acs.est.6b01974 Environ

Gonadotropin-releasing hormone (GnRH) agonists and antagonists, such as leuprolide, goserelin, and triptorelin, temporarily induce a menopause-like state, which significantly reduces estrogen and progesterone levels, leading to shrinkage of fibroids and relief from bleeding and pain

Conversely, taxa enriched in PD, such as members of the Enterobacteriaceae family, Akkermansia, and Desulfovibrio, are associated with heightened lipopolysaccharide burden, mucin degradation, and increased generation of reactive oxygen species, collectively amplifying innate immune activation and pro-inflammatory cascades

Excessive ROS can impair the proper functioning of cellular lipids, proteins, or DNA