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March 5, 2026 Salk Institute researchers find protein that connects GLP-1 agonist drugs to long-term, broad genomic responses that can promote pancreatic health and resilience Salk Institute researchers find protein that connects GLP-1 agonist drugs to long-term, broad genomic responses that can promote pancreatic health and resilience LA JOLLAGLP-1s are building a reputation as wonder drugs. First characterized for their ability to improve insulin release and treat diabetes, the drugs were later found to promote weight loss and improve cardiovascular health

2023;46(Supplement_1):A251-A252

4.1 Clinical relevance of the CLP model The CLP model was selected for its unique ability to recapitulate core clinical features of SAE: polymicrobial sepsis, hippocampal neurodegeneration, and chronic cognitive impairment ( 4.2 Microglia-mediated oxidative neuronal injury Microglial activation initiates neuronal damage, and a previous study revealed that the microglial inhibitor minocycline reduces neuronal apoptosis ( in vivo oxidative stress ( Mechanistically, a microglial inflammation-oxidative stress feedforward loop perpetuates injury: Activated microglia secrete neurotoxins, impairing neuronal mitochondrial function and antioxidant capacity (such as GPX4), thus increasing ROS leakage