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Concurrently, PYY (1-36) activates the Y1 receptor to regulate the expression of apoptosis-related genes (e.g., Bcl2, Nfkb1) and proliferation-related genes (e.g., Crebp), thereby promoting -cell proliferation and protecting -cells from damage caused by stressors such as STZ, high-sugar, and high-fat diets (113, 114)

These gastrointestinal side effects are similar to those of other GLP-1-based medications, with dose escalation generally associated with a greater likelihood of side effects

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At Woodside Internal Medicine , we believe in precision and safety when it comes to metabolic therapies