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* Correspondence: Fang Zeng, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Though several factors could be contributing to the lower rates of weight loss in real-world examples, GLP-1 drugs still result in significant reductions in body weight

This drug may cause side effects, including but not limited to nausea, diarrhea, dry mouth, headaches, decreased appetite, sexual problems

314,315 The dual inhibition of KPT-9274 allows targeting of NAD + regeneration and PAK4 signaling, which are essential for tumor development and survival, making KPT-9274 an attractive drug candidate for use in chemotherapy