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Other damaged neurons were in the pons and mesencephalon, particularly in the tegmental areas of these structures

These reports have been sufficiently concerning that regulatory bodies, including the European Medicines Agency (EMA) and the MHRA, have conducted safety reviews of GLP-1 receptor agonists to assess whether there is a causal link between these medications and suicidal thoughts or self-harm

The receptor that spadin and PE-22-28 primarily bind to is TREK-1 (TIWK-related-potassium channel) which is mostly found in the brain and lung tissue, heart, smooth muscle, prostate, and specific areas of the pancreas