This increased intestinal permeability allows bacterial endotoxins to enter the bloodstream, triggering chronic low-grade inflammation that directly impairs insulin receptor signaling, promotes fat storage, and accelerates the metabolic deterioration associated with obesity and metabolic syndrome
In this condition, the SGLT2is class has demonstrated significant benefits [31, 32], beyond those proven for GLP1-RAs in T2D [33]
Below is an example dose conversion between the two treatments: Always speak to your clinician before making any changes to your medication, including stopping or switching
You should expect follow ups every 4-6 weeks where a clinician will check in on your side effects, hunger cues, weight trends, and metabolic markers, then adjust your dosing as needed