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Notably, Orforglipron (EC 50 1.2 nM), a pyrazolopyridine derivative that acts as a biased partial agonist and is administered orally once daily, has entered Phase III clinical trial (NCT3502970)

If you have been diagnosed with B12 deficiency, are taking metformin, or have recently been told your HbA1c result is unexpectedly low or inconsistent with your symptoms, it is worth raising this with your GP