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One randomised, double-blind study (Badenhorst et al., 2016) found a 55.8% reduction in wrinkle volume and a 32.8% reduction in wrinkle depth after eight weeks of use

Additionally, Gyps inhibit the activation of the Toll-like receptor 4/NF-B signaling pathway and the TGF-1/SMAD2/SMAD4 signaling pathway in orbital fibroblasts, exerting anti-inflammatory and antioxidant effects (163)

Bertheloot D, Latz E (2017) HMGB1, IL-1alpha, IL-33 and S100 proteins: dual-function alarmins

A significant adverse effect to consider with hair dyes is the potential for ACD, manifesting as a facial or scalp eruption or eyelids, forehead, or neck edema