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In contrast, PET MPs ( 150 m) did not induce any microscopic changes in the kidneys of juvenile zebrafish, consistent with the absence of hepatic effects [153]

Fragmented ECM components (e.g., platelet-derived proteins and proteoglycans) generated during tissue remodeling are recognized by immune cells as DAMPs, further amplifying inflammatory and fibrotic signaling via TLR2/4 [318, 319]

This pilot study was therefore designed to generate preliminary data on the apparent efficacy, which could support the design of subsequent larger phase II and III trials

Supporting Collagen Synthesis: Collagen is a major structural protein in tendons, ligaments, and skin