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The enzyme 11-hydroxysteroid dehydrogenase type 1 (11-HSD1), expressed mainly in WAT and liver, catalyses the regeneration of cortisol from cortisone, whereas 11-HSD2 catalyses the reverse reaction [143]

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The primary composite kidney outcome was a decline in eGFR of at least 40% from baseline, renal death, progression to end-stage renal disease or new-onset macroalbuminuria