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Bevan S, Pal T, Greenberg CR, et al

3.2.2 Experimental studies and mechanisms of PD Pathological accumulation of metal ions or a rapid increase in monoamine oxidase B (MAO-B) activity can induce endogenous dopamine (DA) oxidation, leading to -synuclein aggregation, mitochondrial dysfunction, and other factors contributing to the heightened incidence of PD

11 Finally, weight reduction reduces levels of TNF, IL6, and other cytokines secreted by endocrinologic adipose cells and GLP1RAs may have effects on reward pathways and mood that exacerbate psoriasis or its comorbidities (ie, alcohol or substance abuse)

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