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Hypothesis 4 Body composition Retatrutide's glucagon-receptor activation drives some of its weight loss through increased energy expenditure, which is mechanistically associated with sparing more lean mass than pure-satiety pathways

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Compared with normal skin fibroblasts, a greater number of keloid fibroblasts displayed a senescent phenotype and were arrested at the G0/G1 phase using a serum-limited culture approach, indicating the senescent tendency of keloid fibroblasts under simulated ischemic stress