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Reported side effects Mild local irritation or discomfort at the injection site Headache (typically mild and short-lived) Nausea or dizziness in some patients Sweating Mild fever more commonly reported in post-stroke use, generally manageable with standard antipyretics Contraindications Cerebrolysin is not recommended for individuals with: Active epilepsy or seizure disorders Severe renal (kidney) impairment Known hypersensitivity to any component of the formulation Note: A 2023 Cochrane review noted a potentially higher rate of spontaneous adverse events in some stroke trial subgroups

The exception is intensive injury recovery, where extended use until healing milestones is appropriate, followed by a proper rest period

Cao XF, Dai YJ, Liu MY, Yuan XY, Wang CC, Huang YY, Liu MY, Jiang GZ (2019) High-fat diet induces aberrant hepatic lipid secretion in blunt snout bream by activating endoplasmic reticulum stress-associated IRE1/XBP1 pathway

A very limited number of studies have also focused on synoviocytes and synovial fibroblast-like synoviocytes(FLS) models treated with LPS or IL-1