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First and foremost, they must have a Body Mass Index (BMI) of 30 or higher or a BMI of 27 or higher with at least one weight-related health condition, such as diabetes

A tracer was injected intravenously into the diabetes model Ins2AKITA mice to study whether the BBB permeability of diabetic mice was changed by quantifying and visualizing the tracer

Similarly, SURMOUNT 3 showed a mean BW reduction of 18.4% with tirzepatide titrated to the maximum tolerated dose (15 mg for 86% participants) after a 72-week follow-up 35

Dietary composition also likely plays a part in gut motility, as indicated by differential gut manometry responses to FODMAP infusions in IBS patients compared to healthy controls (38)