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CADTH-developed search filters were applied to limit retrieval to health technology assessments, systematic reviews, meta-analyses, indirect treatment comparisons, any types of clinical trials or observational studies, or economic studies to a secondary search of the concepts semaglutide and type 2 diabetes

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The primary mechanism of action involves stimulating insulin secretion from the pancreas when blood glucose levels are elevated, whilst simultaneously suppressing the release of glucagon, a hormone that raises blood sugar

Baloch ZW, LiVolsi VA