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Histopathologically, medication-induced melanin pigmentation is characterised by the presence of melanin within the lamina propria either as free granules or within melanophages, but without melanocytic hyperplasia
Cannabinoid receptors are widely expressed in islets of Langerhans, and several studies have investigated specific distribution and mechanisms of CB1 versus CB2 receptors in relation to pancreatic endocrine functions 62,63,64
230 Restless legs syndrome (muscle restlessness with a desire to move the limbs, especially at night) is estimated to affect 3% of the general population, with higher prevalence in women and older individuals
DSIP Delta Sleep-Inducing Peptide is naturally produced in the brain and plays a direct role in sleep architecture
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