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Fascinatingly, the Survodutide studies that I mentioned previously, they measured the number of patients in the placebo group that ultimately were taking another GLP-1 on their own accord and that actually led, that was 20% of that placebo group by the end of the trial actually were taking a GLP-1

Pancreatology 22 , 880886 (2022)

And what I mean by that is there is an over about a 200% increased risk of major depression in these individuals on the drug versus placebo, as well as an over 100% increased risk of anxiety and even suicidal behaviors