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LEADER, liraglutide effect and action in diabetes: evaluation of cardiovascular outcome resultsa long-term evaluation

The authors concluded that treatment with a single dose of sitagliptin, in patients already treated with the GLP-1RA liraglutide, resulted in elevations in intact GLP-1 and GIP plasma concentrations after a mixed meal test, but without changes in insulin, C-peptide, glucagon and glucose concentrations

C'est pour cette raison qu'un fournisseur proche gographiquement est prfrable : un transit court limite les variations thermiques