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Brecka also points to the value of blood work and biomarkers when deciding what type of nutritional support may be helpful

Targeting FIT2, a protein essential for LD formation, the authors demonstrated reducing LD accumulation in brain macrophages could restore their pathological phenotypes in an AD mouse model (Wu et al., 2025)

To compare metformin for weight loss, one study measured weight loss after six months of metformin up to a dose of 2,500 mg daily

A high prevalence of TD has been reported among both type 1 DM (T1DM) and type 2 DM (T2DM) patients ( GLP-1 is an amino acid peptide hormone secreted by L cells of the gastrointestinal mucosa that promotes insulin secretion, suppresses glucagon secretion, and delays gastric emptying ( GLP-1 receptor agonists, a new type of antidiabetic drug for treating T2DM in recent years, with additional benefits of weight loss and blood pressure reduction ( Methods Data Sources and Searches We searched PubMed (MEDLINE), EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL) and Web of Science from database inception to 31 October 2021 to identify eligible RCTs without restriction of language or publication period