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Rat peritoneal mast cells were also treated with pterostilbene (1, 10, 50, 100 M) and no effect on cell viability was observed, however degranulation and IL-6 expression was inhibited [209]

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The primary outcome was the time to primary failure defined as an A1c 7% over an anticipated mean observation period of 5 years The results as expected demonstrated that the GLP-1 receptor agonist liraglutide was more effective than the sulfonylurea glimepiride and the DPP4 inhibitor sitagliptin in maintaining the A1c 180 mg/dl (i.e., secondary failure) (31)

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