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People with MC4R deficiency responded to tirzepatide similarly to those with a normal MC4R genotype, demonstrating the effectiveness of tirzepatide in this subgroup of people with obesity (Fig

Common baseline checks include A1c or glucose status, kidney function, liver enzymes, lipids, blood pressure, weight, waist circumference, medication review, pregnancy status when relevant, and individualized testing for symptoms such as thyroid concerns or gallbladder history

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The answer depends on several factors that only a qualified provider can evaluate in the context of your specific health history and goals