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1 Introduction Epilepsy is a chronic disorder of the central nervous system (CNS) affecting approximately 65 million individuals worldwide ( Seizures are caused by an acute pathological insult or lesion that leads to a series of changes in molecular, cellular, and physiological properties, including inflammation (Vezzani et al., 2011), blood-brain barrier (BBB) injury ( The mechanisms underlying neuronal loss during epilepsy include oxidative stress, inflammation, iron overload, and excitotoxicity (Zecca et al., 2004