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The MLR in the midbrain plays a crucial role in initiating and regulating locomotion speed, comprising three subregionscuneiform nucleus (CnF), pedunculopontine nucleus (PPN), and mesencephalic reticular formation (mRT) 84,85

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It plays a role in the response to oxidative stress by protecting cells from free radicals and stabilising redox in the intracellular environment (Bryukhanov et al

The activation of GLP-1R can reduce the size of cerebral infarction by enhancing cell survival signaling pathways, reducing ischemia-reperfusion injury, promoting brain repair, and inhibiting inflammatory response and oxidative stress ( 4.4 Tumors The role of GLP-1RA in tumor remains controversial