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While ERAD is largely associated with the degradation of unwanted byproducts of protein biosynthesis, including misfolded and unassembled proteins, and safeguards protein maturation, it is now apparent that ERAD also regulates the abundance of folding-competent proteins as a means to fine-tune key physiological processes, suggesting that ERAD constitutively functions to ensure both protein quality and quantity

doi: 10.1038/s41574-021-00507-z 94 PromratKKleinerDENiemeierHMJackvonyEKearnsMWandsJRet al