Ethics statement The requirement of ethical approval was waived by the University of Wisconsin Madison Institutional Review Board for the studies involving humans because this is a retrospective chart review project
L-Carnitine and CLA supplements offer a range of benefits, including improved exercise performance, enhanced energy production, reduced body fat, increased lean muscle mass, better cognitive function, and improved heart health
It also alters melanin production from eumelanin (dark pigment) to phaeomelanin (lighter pigment), which contributes to its skin-brightening effect.(2) This mechanism explains why its often promoted as a depigmenting agent for issues like melasma, sun spots, and post-inflammatory hyperpigmentation
Professor Adam Balen from the Royal College of Obstetricians and Gynaecologists emphasizes: "A clinician may consider prescribing this medicine 'off-label' if they think it would benefit a patient with PCOS, but this would need a careful discussion with them about the benefits and potential risks." Beyond the physical benefits, these treatments are reshaping how patients view their condition
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