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It is unlike most antioxidants in that it is created in the liver

ODriscoll histological assessment Histological findings ( n = 8 at each time point) for each section were evaluated and scored by three investigators according to ODriscoll histological grading parameters (cell morphology, matrix staining, structural integrity, thickness/defect filling, osteochondral junction, adjacent bonding, basal integration, cellularity, clustering/distribution, and adjacent cartilage) to quantitatively evaluate the extent of cartilage repair based on the criteria of predominant tissue type, structural properties, freedom from degenerative changes in the neighboring cartilage, and freedom from cellular changes of degeneration [26]

On the other hand, a significant increase in TDO expression has been found in preeclampsia, but since inflammatory response is involved in the pathogenesis of preeclampsia, it can be hypothesized that upregulation of TDO cannot fully compensate for the decrease in IDO in this regard