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Biomarkers correlating the lower IGF-1 concentration to increased waist-to-hip ratio or to impaired glucose tolerance are also being studied [224, 225]

Oral semaglutide (Wegovy) also provides significant weight loss when used as prescribed by your healthcare professional

Given these concerns, the JDS has issued the "Recommendations for Safe Use of Incretin-Based Therapies, Second Edition" (Table 1) [13] emphasizing that careful consideration of hypoglycemia risk, remaining -cell function and mass, gastrointestinal side effects is essential when determining tirzepatide indications and treatment continuation

Regular monitoring allows both you and your healthcare team to assess therapeutic response, identify potential adverse effects early, and make informed decisions about dose adjustments or continuation of therapy