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When taken as a medication, GLP-1 mimics this hormones effects, helping patients feel full sooner and stay satisfied longer

In fact, IGF-1 may support hair follicle health in some cases, though this isn't a primary use

### Semaglutide Mechanism of Action Semaglutide achieves **weight loss** through multiple complementary pathways: - **Central appetite suppression** acts on hypothalamic GLP-1 receptors to reduce hunger and increase satiety - **Delayed gastric emptying** slows stomach emptying, prolonging feelings of fullness - **Improved insulin sensitivity** reduces insulin resistance and promotes healthy glucose metabolism - **Reward pathway modulation** reduces cravings and food-seeking behavior by acting on mesolimbic dopamine circuits - **Potential direct effects on adipose tissue** emerging research suggests GLP-1 may directly influence fat metabolism For a complete breakdown of semaglutide's dosing protocol, see our [semaglutide dosing schedule week-by-week guide](/guides/semaglutide-dosing-schedule-week-by-week-guide)

Designing trials to test microdosing in MS will be complex, and ensuring compliance (since even microdoses, still being Schedule I substances, would have to be managed closely) is non-trivial