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Because rapid jumps to maintenance levels dramatically increase nausea, vomiting and pancreatitis risk, while the stepped approach lets the body adapt

Rather than aggressive calorie restriction, which risks malnutrition and muscle loss, a moderate energy deficit of 500-600 calories per day is generally recommended

For example, general control nonderepressible 2 (GCN2) is activated by amino acid starvation, whereas protein kinase-like endoplasmic reticulum kinase (PERK) is activated by endoplasmic reticulum (ER) stress 15

This can result in a depletion of amino acids and key nutrients (such as zinc, selenium, B12, and iron/ferritin) needed for thyroid support, as well as for the synthesis of non-essential amino acids