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Instead, theyre marketed as over-the-counter support supplements

The search included terms such as small molecule GLP-1 receptor agonists, oral GLP-1 receptor agonists, Danuglipron, Orforglipron, and Aleniglipron. Additionally, information on ongoing clinical trials involving small molecule GLP-1 receptor agonists was retrieved from the ClinicalTrials.gov database using the same keywords

Berberine may also interact with various medications, particularly those metabolised by cytochrome P450 enzymes, so consult your GP or pharmacist before use

One of the most common side effects people experience on these medications is nausea