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NHS England has specifically warned against off-label prescribing of Ozempic for weight loss, partly due to concerns about supply disruption for T2D patients and partly because the licensed weight management alternatives Wegovy and Mounjaro are available and appropriate

Comparison of the effects of glucagon-like peptide receptor agonists and sodium-glucose cotransporter 2 inhibitors for prevention of major adverse cardiovascular and renal outcomes in type 2 diabetes mellitussystematic review and meta-analysis of cardiovascular outcomes trials

Those are the signs that the compound is active and the cascade has begun

Kraft et al., 2004)