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Next, the trypanothione synthetase (TryS) enzyme catalyzes an ATP-dependent two-step reaction in which two GSH molecules and a polyamine (spermidine) are used to synthesize T[SH] 2 in cytosol of the parasite (Oza et al., 2 molecules deliver reducing equivalents to peroxidases and other enzymes responsible for neutralizing ROS, and the oxidized form of trypanothione is reduced by trypanothione reductase (TryR) in presence of NADPH produced by the pentose phosphate pathway (PPP) (discussed below and reviewed in Irigon et al., 2 , TryS, and TryR are attractive drug targets for control of trypanosomes

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To sum up, EX can reduce the weight of diabetic patients with or without obesity, and it can also reduce the weight of simple obesity and polycystic ovary syndrome/metabolic syndrome with obesity