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The risk of NAION needs to be taken into account and may help to decide about a more conservative approach in the definition of beginning semaglutide for those subjects without a clear indication for that. When looking at the results of these studies, Bert said its important to note that when looking at the increases of percentages, it demonstrates that it is still very, very rare for a condition like NAION to occur

The GLP-1 receptor arm drives glucose-dependent insulin secretion alongside suppression of pancreatic alpha-cell glucagon output, slows gastric emptying, and engages central nervous system appetite-modulating circuits in the hypothalamus and brainstem (PMID 39515565)

The FDA also alerted doctors nationwide so they can counsel expectant parents with better information

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