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The latter includes interaction with the AR DBD and thereby inhibiting the transcription of ARE-driven genes, the AR-HOXB13 complex conferring androgen responsiveness to genes that harbor a HOXB13-response element, and synergy with AR to enhance the transcription of genes that contain a HOX element adjacent to an ARE [79]

These data collectively suggest that the inhibitory effect of GSSG on the NF-B signaling pathway, via suppression of IKK- activation, is mechanistically implicated in the increased sensitivity of hepatocytes to TNF killing

Sharma P, Kumar A, Sharma BC, Sarin SK