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Medical Conditions Associated with Homocysteine Imbalance Certain medical conditions can disrupt the methionine-homocysteine cycle, leading to elevated homocysteine levels (hyperhomocysteinemia) or impairments in methylation and detoxification

The cells were devoid of glutathione, but were fully viable and showed a phenotypic switch, the latter only in MITF-expressing B16F1 cells and not in MITF-deficient D4M3A.781 cells

W.RedeckerC.et al (2017)