In a phase 3, multicenter, double-blind, placebo-controlled trial of once weekly exenatide versus placebo, no significant between-group differences were observed on the Unified Dyskinesia Rating Scale [34]
The adverse effect profiles of these treatments do not overlap significantlyOzempic commonly causes gastrointestinal symptoms such as nausea, vomiting, and diarrhoea, whilst botulinum toxin may cause localised injection site reactions, temporary muscle weakness, or headache
UK approval will likely follow that, so realistic availability is 2027 at the earliest and with private prescription first
In addition, LDHA blockade also plays a role in the regulation of the OA microenvironment (i.e., hypoxia, acidity, high HIF-1)