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The transporters regulated by WNK kinases include the sodium potassium chloride cotransporter type 2 (NKCC2: encoded by the SLC12A1 gene), the sodium chloride cotransporter (NCC: encoded by the SLC12A3 gene), the epithelial sodium channel (ENaC: composed of three subunits encoded by the SCNN1A, SCNN1B, and SCNN1G genes), and the aldosterone-responsive renal outer medullary potassium channel (ROMK: encoded by the KCNJ1 gene)