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Endoscopic Submucosal Dissection (ESD) Procedure, HCPCS Code C9779 (APC 5303) We established HCPCS code C9779 ( Endoscopic submucosal dissection (ESD), including endoscopy or colonoscopy, mucosal closure, when performed ) effective October 1, 2021, to describe the endoscopic submucosal dissection (ESD) performed during an endoscopy or colonoscopy