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Materials and Methods Screening of Active Phytochemical Ingredients NSS was provided by Imtenan Heath Shop Company, Obour City, Egypt

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4.2 Regulation of ferroptosis by inflammatory cytokines and immune signaling 4.2.1 Classic proinflammatory cytokines IL-1 can induce the synthesis of matrix-degrading enzymes MMP-13 and ADAMTS-5 by chondrocytes and synovial cells (117)