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Modest Human Weight Loss (Phase 2 Data) Evidence quality: Moderate (one phase 2b trial, 300 patients) In a 12-week, randomized, double-blind, placebo-controlled trial with 300 obese adults across five sites, oral AOD-9604 produced measurable but modest weight loss

Specifically, time-to-on, or a latency from the treatment intake to the patient turning to on-state has been recognized as a major contributor to total daily off-time [11], and SC apomorphine treatment has been shown to rapidly and significantly reduce time-to-on in patients with Parkinsons disease experiencing delayed onset of their morning levodopa dose [29], which is consistent with the present data

It is a synthetic version of the naturally-occurring growth hormone-releasing hormone, and has been found to be safe and effective in clinical trials

Pai and Dubhashi 2013)