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Data collection was performed at beamline P11 at the Petra III storage ring (Deutsches Elektronen-Synchrotron, Hamburg, Germany) (Burkhardt et al., 2016)

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Research demonstrates that IGF-1 LR3 activates the same downstream pathways as native IGF-1, primarily the PI3K/Akt/mTOR and Ras/MAPK/ERK cascades, but with greater potency due to its prolonged receptor availability